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Neurodevelopment disorders

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Mitochondrial and Metabolic Abnormalities in Neurodevelopmental Disorders Daniel A. Rossignol and Richard E. Frye

Neurodevelopmental disorders such as autism spectrum disorder (ASD), dyslexia, learning disabilities and developmental delays affect a significant percentage of children and are associated with long-term psychological and physical disability. ASD research has primarily concentrated on and continues to concentrate on genetic causes of ASD. Recent studies have expanded the recognition of the abnormalities associated with ASD, implicating broader systemic issues involving immune and redox dysregulation, oxidative stress and impaired energy generation systems.

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