Recent research has implicated systematic physiologAdd Newical and metabolic abnormalities, such as immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and other metabolic disorders that transcend organ specific dysfunction in ASD. In this context, ASD may arise from, or at least involve, systemic physiological abnormalities. Mitochondrial dysfunction and cerebral folate abnormalities are the most prevalent metabolic disorders affecting children with ASD.