I recently came across this compelling tweet: “An open question on mental health as a junior psychiatrist. What do you think I should learn and focus on to be a better doctor and advocate for my patients?” Could there possibly be a better question for all people starting out in any field to ask themselves, and others, as they embark on their careers? The 140-character limit imposed by Twitter forced me to offer only a brief reply containing five scant snippets of advice. This troubled me-his serious request deserves a more serious response. Here it is-the 50 most important things I have learned in my 50 years studying psychiatry: